A Master's Thesis in the College of Medicine Deals with the Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) on Oxidative/Antioxidant States
The College of Medicine discussed a master’s thesis of the Department of Pharmacology on the effect of selective serotonin reuptake inhibitors (SSRIs) on oxidative/antioxidant states and some inflammatory markers for patients with depression which was presented by the student Rahma A. Al-Kasso, on Monday, 13th September 2021.
The thesis aimed to assess the oxidative stress status and antioxidant status as well as the evaluation of some inflammatory markers for depressive patients with access to the effect of sertraline on the oxidative stress status, antioxidant status, and some inflammatory markers for these patients.
The study found that depressed patients had a higher level of the oxidative stress marker malonaldehyde and a lower level of total antioxidants than the control group. Thus, taking antidepressants (sertraline) for two months leads to a significant improvement in the oxidative stress/antioxidant status and the clinical course of the inflammatory response by reducing signs of inflammation. Therefore, selective serotonin reuptake inhibitors (SSRIs) may provide new concepts in the treatment of depression through their role as an antioxidant and immunosuppressive in addition to its role as an antidepressant.
The discussion committee consisted of Prof Dr Mahfouz S. Al-Saydan (Chairman), Assistant Prof Dr Walid Gh. Ahmed (Member), Assistant Prof Dr Mus'ab M. Khalaf (Member), and Assistant Prof Dr Qassim S. Abdullah (Member and Supervisor).
Part of the discussion was attended by the Dean of the College, Prof Dr Basil Mohammednather Saeed, the Scientific Vice-Dean, Assistant Prof Dr Humam Gh. Ibrahim, and the Administrative Vice-Dean, Assistant Prof Dr Hazim Kh. Al-Allaf. It was also attended by some heads and teaching staff of various scientific departments and a number of postgraduate students.
After the discussion, the committee's decision was read included accepting the thesis after doing the necessary amendments and awarding the student the master's degree.